DR FILIP JELEN
Chief Executive Officer
Pure Biologics is a specialized contract research organization with expertise in recombinant protein production, purification and biophysical analyzes. We proved ourselves in this field successfully completing tens of research projects and collaborating with entities worldwide.
We have a great track record of successful generation and formulation of recombinant proteins and antibodies at their discovery stage as drug candidates for preclinical studies or diagnostics. Together with detailed biophysical characterization of biologics, protein engineering and custom assay development abilities, we serve our numerous collaborators not only as a service provider, but primarily as a professional think tank and R&D partner solving complex protein related problems.
The key to our success in delivering active, homogenous and biocompatible protein preparations is skillful application and connection of array of approaches. Starting from bioinformatics through selection of appropriate expression platforms, purification strategies, applying sophisticated prep analytics in every stage of process development.
German Days on Biotechnology is the biggest biotech conference in Germany. We gave a lecture about biotech industry in CEE and shared our insights on entering the German biotech market.
As member of BIO Deutschland we took part at AGM. Dr. Filip Jeleń, CEO of Pure Biologics, presented his candidacy for board of directors of this cluster, in front of the German biotech companies' representatives.
Pure Biologics is member of biotech cluster in Saxony. In the end of June we took part in the general assembly and also in summer party, networking with other cluster members.
Pure Biologics was the silver sponsor and exhibitor at 17th CABS Annual BioPacific Conference in the San Francisco Bay Area at San Mateo.
Pure Biologics is a team of extremely talented and energetic people, who are passionate about pursuing each new project. Our high success rate in solving complex protein related problems inherent in the their development process, comes from our intransigence, thorough analysis of the literature prior to each project, complement skills, as well as the quality of experiments design and their perfect execution.
Since our very beginning, we were able to build a team of specialists in the field of biotechnology, protein engineering, molecular biology, cell culture, and in vitro selection from different libraries. Many of our employees have an international experience and/or PhD.
We are convinced, that people working with us are amazing experts and that there are no impossible for them. Our employees are the reason we were able to sustain partnership with multiple clients in Poland and abroad. Over 50% of our projects are international projects, therefore our employees have the opportunity to exchange the experience with many experts outside Poland.
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We do not forget about the youngest members of our team, constantly taking care about their development and encouraging them to gain more experience. We are giving them the opportunity to prove to be a reliable project managers during their independent projects.
We are constantly looking for new specialist to join our team. For our candidates from Poland we prepared the brochure to explain the process of recrutation in PB (and to make it less stressful) - Recruitment process in PB (in Polish only). Our current vacancies are enlisted below. We encourage you to apply independently as well, by sending your CV and LM to email@example.com.
Press note 1
Proteins are high molecular weight molecules composed of amino acids. They are the building blocks of all living organisms and play role in all their crucial functions. Due to their complexity, their production in the laboratory, demands technologies utilizing living microbes or cells. Recombinant protein is obtained by DNA recombination using variety of molecular biology techniques. It is the first step in the protein production in vitro. The subsequent ones are: protein expression (its biosynthesis in bacterial or mammalian cells) and purification (proteins chromatography).
Pure Biologics – specialized contract research organization - offers protein production and contract research services with a main focus on high quality contract protein manufacturing for preclinical studies of biological drug leads or for diagnostics development. As a company offering custom proteins we effectively respond to the needs of pharmaceutical and biotech companies, as well as research institutions, for which recombinant protein production is usually crucial for scientific objectives. Another strong branch of our services is a detailed analysis of proteins.
It often happens that not the protein downstream processing or protein purification itself is the most challenging step, but its efficient production in soluble form to maintain biological activity. Thus, Pure Biologics offers proprietary methodology allowing for protein refolding, i.e. renaturation of inactive proteins produced in insoluble form.
Currently, recombinant monoclonal specific antibodies constitute the most important group of biopharmaceuticals/biologics. The standard, classical way of antibody development is still done through animal immunization. Even though protein engineering allows for antibodies humanization, they still exhibit many side effects. Therefore, Pure Biologics offers recombinant antibody development by an alternative in vitro approach – antibody selection from libraries using Phage Display technology. Human recombinant antibodies obtained by this way are often characterized by better affinity parameters than those arising from classical methods.
As professionals and enthusiasts, we are constantly extending our portfolio of services. Pure Biologics also offers: protein analytics, assay development, assessment of enzymatic activity, affinity measurements, protein stability measurements and protein conjugation. We mastered many proteomics approaches for protein identification, direct mass measurement and protein sequencing using mass spectrometry service (MS analysis). Pure Biologics has also long-term experience in bioinformatics analysis and genome sequencing projects.
Press note 2
Pure Biologics is a specialized Contract Research Organization & CMO with expertise on proteomics, particularly on protein engineering, efficient recombinant antibody and recombinant protein production.
The company provides a complete gene to protein service. Starting from vector construction with applicable molecular biology methods, through protein expression and protein purification using proteins chromatography we deliver pure custom proteins with the highest quality. In cases where the protein downstream processing results in getting recombinant protein in insoluble form as inclusion bodies, lacking its native structure and biological activity, the company has unique expertise in protein refolding. Together with detailed analysis of proteins and custom assay development, we offer a wide range of services to companies in the biotech and pharmaceutical industries which conduct research on biologics as potential drug candidates in preclinical studies. We mastered also methods for antibody selection through Phage Display to obtain specific antiobodies for biomedical and diagnostic use. Recombinant antibodies obtained by this way, instead of classical immunization, are often characterized by better affinity parameters.
The company is mainly focused on protein production and antibody development services. Apart from contract protein manufacturing, we provide services on protein analytics and protein conjugation. Pure Biologics offers a comprehensive range of bioanalytical protein characterization methods, including protein sequencing using mass spectrometry service (MS analysis), studies of enzymatic activity, protein stability and affinity measurements. Our team of specialists is also experienced in bioinformatics and genome sequencing projects.